A Clinical Study for People with Crohn’s Disease

If you or a loved one has Crohn’s Disease, you may be eligible to participate in the EXPLORER 2.0 clinical research study.

Find Out If You Qualify Apply to Join the Study

About the Study

What Is the EXPLORER 2.0 Clinical Study?

Researchers are studying the effect of vedolizumab intravenous (IV) in combination with either adalimumab or ustekinumab in adults with moderate to severe Crohn’s Disease. The study aims to assess the effectiveness of dual targeted treatment followed by vedolizumab alone.

Open to individuals aged 18-65 with moderate to severe Crohn’s Disease

Participants will receive vedolizumab together with either adalimumab or ustekinumab in Part A

Participants who respond to the treatment in Part A will receive vedolizumab alone in Part B

Study participation lasts up to 76 weeks

No placebo is involved

All study-related care and medication are provided at no cost

Eligibility Criteria

Who Can Participate?

You may qualify if you:

Are 18-65 years old

Have had Crohn’s Disease for at least 3 months

Have not responded well to previous treatment with ustekinumab, risankizumab, infliximab (or biosimilar), adalimumab, or certolizumab pegol

Do not have short bowel syndrome, ulcerative colitis, an abdominal abscess, or a perianal fistula with abscess

Have not had a colon resection within 6 months of study participation

Have not undergone gastric bypass surgery

Have not had an organ transplant

Additional entry criteria will be discussed with the study doctor.

Learn More About Eligibility Criteria Apply to Join the Study

What to Expect

What's Involved in the Study?

Physical exams and health assessments

Blood, urine, and stool sample collection

lleocolonoscopy with biopsy

ECG (electrocardiogram) to monitor heart function

Chest X-ray or CT scan

All medical tests and investigational study medicine will be provided at no cost.

Frequently Asked Questions

What is the clinical trial testing?

Vedolizumab, Adalimumab, Ustekinumab

How many participants are being enrolled?

150

Are placebos part of the clinical trial?

When is the clinical trial being conducted?

Apr 2024 – Jun 2027

How long is participation in the clinical trial?

Participants will be in this study for up to 76 weeks.

Apply to
Join the Study

To learn more about the study, check eligibility, or participate, click on your preferred location below and complete the form on that page.