Primary Sclerosing Cholangitis (PSC)

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Primary sclerosing cholangitis is similar to PBC (primary biliary cholangitis) but it affects the bile ducts inside and outside the liver. It causes the bile ducts to become inflamed, scarred, and narrowed which can eventually lead to liver cirrhosis.

Bile is important to the way the body functions. It helps with digestion and rids your body of bad cholesterol, toxins, and worn-out red blood cells. That is why it is vital that you receive treatment for PSC as soon as possible.

Learn more about PSC and the various ways that it affects your life by scheduling an appointment with a gastroenterologist at GI Alliance when it is convenient for you.

It is still unclear what causes PSC, but it is thought to be an immune response to a toxin or infection. PSC has a genetic predisposition, meaning if a family member has or had PSC, you are more likely to have it as well. Risk factors of PSC include:

  • Age (PSC is most commonly diagnosed in people between ages 30 and 50)
  • Being a man
  • Having IBD
  • Heritage (people with Northern European heritage are at higher risk of getting PSC)


To understand and learn more about the different causes of PSC, contact the GI specialists at GI Alliance to schedule a consultation.

PSC is most commonly diagnosed before any symptoms appear during a routine test for other conditions. Treatment of PSC is more effective when caught earlier. The early symptoms of PSC could include fatigue and itching. Some other common symptoms of PSC include:

  • Swollen feet and ankles
  • Joint pain
  • Muscle soreness
  • Dry eyes
  • Dry mouth
  • Jaundice (yellowing of the skin or eyes)
  • Dark skin not related to sun exposure
  • High cholesterol
  • Dark and greasy stools
  • Brittle bones
  • Pain in the upper right abdomen
  • Chills
  • Night Sweats
  • Unwanted weight loss

It is important to request an appointment with your nearest GI Alliance gastroenterologist if you have intense itching on much of your body, or if you feel very tired all the time. It is especially important to bring these symptoms up to your doctor if you have a type of inflammatory bowel disease such as ulcerative colitis or Crohn’s disease.

The medical community has not found a cure for PSC. Most of the treatments involve treating the narrowed bile ducts and the symptoms and complications associated with the disease. Treatments for PSC include the following:

  • Relieving itching symptoms with topical creams
  • Antibiotics for infections
  • Balloon dilation for narrowed bile ducts
  • Stents for narrowed or blocked bile ducts
  • Nutrition support
  • Liver transplant
  • Avoid Alcohol
  • Exercise
  • Maintain a healthy weight
  • Surgery to temporarily open blocked bile ducts
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As a chronic liver condition, primary sclerosing cholangitis can impact your health and wellness in a number of ways, and it can lead to further health issues in the absence of care. However, our team is ready to provide the personalized care you need to help improve your quality of life. For additional information on the treatments available to you, contact your nearest GI Alliance location to connect with a gastroenterologist.

Dr. Cluley helped me overcome a condition that had been plaguing me for over a month. He did so by listening to me, carefully analyzing my lab results, and weighing all the available courses of action. I knew from the minute he walked into the room that I was in good hands. He didn’t rush our meeting, and he and his staff followed up with me and were available to answer questions whenever I needed them.

F.R. Google

I just recently started going there for a complicated issue and Dr Shaughnessy and his staff go above and beyond. My issue landed outside their practice and still they continue to lead me in the right direction. Thank you so much all of you. Keep being great people

L.L. Google

My first colonoscopy which went very well. Dr Arndt and his staff were wonderful

C.O. Google

Super understanding doctor. Long appt. times though. Things have been getting better for me but more due to my own research. Still having issues.

F.T. Google

Very professional team. Look forward to my next visit.

C.E. Google

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