Crohn's Disease

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What is Crohn’s disease?

Crohn’s disease is a part of a group of conditions called inflammatory bowel disease (IBD). It causes uncomfortable inflammation of the digestive system. The condition commonly involves the small bowel and colon, but it may impact any part of the gastrointestinal (GI) tract from the mouth to the anus. Crohn’s disease is different from the other form of IBD known as ulcerative colitis.

Crohn’s disease can affect the entirety of the bowel wall and spread into deeper layers of the affected bowel tissue. This gastrointestinal condition can be very painful and possibly lead to more serious complications. If you or a loved one suffer from the symptoms of Crohn’s disease, please contact a GI Alliance location near you. Our board-certified gastroenterologists are dedicated to helping patients improve their quality of life with effective treatment options.

What causes Crohn’s disease?

The exact cause of Crohn’s disease is still unknown. There are, however, some factors that seem to influence the onset of Crohn’s disease and its symptoms.

  • Immune system: It is likely that internal bacteria or viruses can trigger Crohn’s disease. When your body activates your immune system to fight a virus or bacteria, an abnormal immune response can attack the cells in the digestive system as well. As a result, portions of the small intestine and the colon become inflamed.
  • Genetics: You may inherit genes from your parents that place you at a higher risk of developing Crohn’s disease. As many as 20% of people with Crohn’s disease have a relative who also has the condition or another inflammatory bowel disease. It is most common in people between the ages of 20 and 30.

What are common symptoms of Crohn’s disease?

Most symptoms associated with Crohn’s disease develop gradually, and they range from mild to severe. Crohn’s disease symptoms can include:

  • Blood in the stool
  • Rectal bleeding
  • Diarrhea
  • Fever
  • Abdominal pain
  • Stomach cramps
  • Mouth sores
  • Pain or drainage near or around the anus
  • Constipation
  • Sudden weight loss
  • Loss of normal menstrual cycle
  • Poor development in children

You should contact your closest GI Alliance location immediately if you notice persisting changes in your bowel habits, or you have any of the following symptoms:

  • Blood in your stool
  • Persistent and/or severe abdominal pain
  • Unexplained weight loss
  • Fever lasting more than a day
  • Persistent diarrhea

How is Crohn’s disease treated?

There is currently no cure for Crohn’s disease and treatment will vary from person to person. The main objectives of Crohn’s disease treatments are to control the inflammation that triggers symptoms, and then achieve and maintain remission. In the best cases, the disease can go into long-term remission in a patient who receives proper care. Crohn’s disease may be treated with one or a combination of the following treatment approaches.

Antibiotics: Antibiotics can help destroy bacteria that trigger the abnormal immune system response that causes inflammation. These are not a mainstay of therapy but may be used in conjunction with other therapies.

Anti-inflammatory medications: Corticosteroids or steroids may be used to address inflammation while choosing a long-term treatment option. Corticosteroids help reduce inflammation in the body and can be used in combination with immune system suppressors.

Long-term anti-inflammatory therapies: These therapies address the body’s abnormal immune response to bacteria and viruses. Some of the immunosuppressant drugs your GI Alliance gastroenterologist might prescribe include azathioprine, infliximab, adalimumab, certolizumab, methotrexate, natalizumab, vedolizumab, and ustekinumab.

Nutrition: Your gastroenterologist might recommend a special diet to help with symptoms and aid in induction of remission.

Surgery: Some patients with Crohn’s disease may need surgery to treat blockages, fistulas, infection, or bleeding if medication is not helping. Others may need surgery to remove the diseased area of the intestine.

Medications for symptoms: Certain medications and supplements may also be recommended to help manage Crohn’s disease symptoms. These may include:

  • Iron supplements
  • Anti-diarrheals
  • Vitamin B-12 shots
  • Calcium and vitamin D supplements
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Does Crohn’s disease cause health complications?

Intestinal blockage can occur in people with Crohn’s disease. A blockage occurs because the intestinal wall thickens or swells from inflammation and scar tissue. Ulcers can also cause tunnels that may form through inflamed areas of the intestine to surrounding intestines or even other organs.

If you have Crohn’s disease, you might have insufficient amounts of protein, vitamins, or calories in your diet. This may occur because you may not be able to absorb nutrients from the food you consume, you have an upset stomach keeping you from eating enough food, or you may be losing protein through the intestine.

Other complications of Crohn’s disease can include:

  • Arthritis
  • Skin problems
  • Swelling in the eyes or mouth
  • Kidney stones
  • Gallstones

Is Crohn’s disease fatal?

Crohn’s disease is not a fatal disease. However, if left unmanaged and untreated, over time, a person with Crohn’s disease can develop health complications that can be fatal. GI Alliance has several clinical trials and care programs underway to help manage the symptoms and improve the lives of those living with Crohn’s disease.


Expert care for Crohn's disease

At GI Alliance, we understand the impact Crohn’s disease can have on your general health and day-to-day life. Our physician-led network of gastroenterologists specializes in treating GI conditions like Crohn’s disease and is dedicated to providing expert, personalized care to each of our patients. To connect with a physician who treats Crohn’s disease, please contact your local GI Alliance office today.

Dr. Ramesh is awesome!! He truly cares about his patients. I've had Crohns Disease for 28 years and he is the best Gastroenterologist I've ever had. HIGHLY recommend!!

W.L. Google

Like the way that the facility is now set up during the Pandamic.

S.O. Google

Dr Petro was thorough & conveyed my results in an understandable way.

W.P. Google

Dr Mehta was great in his handling of my colonoscopy last week. Will see him in a year or so. Very knowledgeable.

W.S. Google

Honestly one of the best doctors I’ve ever been to in my life, probably the best. Was so comforting, relatable, and kind. He actually listened to you and took time to understand. Amazing person and I can’t recommend enough

Z.G. Google


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